WHAT?
There's a fascinating piece up at Wired on the Placebo Effect. Apparently, it's getting--strangely enough--stronger. Steve Silberman writes:
MK-869 wasn't the only highly anticipated medical breakthrough to be undone in recent years by the placebo effect. From 2001 to 2006, the percentage of new products cut from development after Phase II clinical trials, when drugs are first tested against placebo, rose by 20 percent. The failure rate in more extensive Phase III trials increased by 11 percent, mainly due to surprisingly poor showings against placebo. Despite historic levels of industry investment in R&D, the US Food and Drug Administration approved only 19 first-of-their-kind remedies in 2007—the fewest since 1983—and just 24 in 2008. Half of all drugs that fail in late-stage trials drop out of the pipeline due to their inability to beat sugar pills.
The upshot is fewer new medicines available to ailing patients and more financial woes for the beleaguered pharmaceutical industry. Last November, a new type of gene therapy for Parkinson's disease, championed by the Michael J. Fox Foundation, was abruptly withdrawn from Phase II trials after unexpectedly tanking against placebo. A stem-cell startup called Osiris Therapeutics got a drubbing on Wall Street in March, when it suspended trials of its pill for Crohn's disease, an intestinal ailment, citing an "unusually high" response to placebo. Two days later, Eli Lilly broke off testing of a much-touted new drug for schizophrenia when volunteers showed double the expected level of placebo response.
It's not only trials of new drugs that are crossing the futility boundary. Some products that have been on the market for decades, like Prozac, are faltering in more recent follow-up tests. In many cases, these are the compounds that, in the late '90s, made Big Pharma more profitable than Big Oil. But if these same drugs were vetted now, the FDA might not approve some of them. Two comprehensive analyses of antidepressant trials have uncovered a dramatic increase in placebo response since the 1980s. One estimated that the so-called effect size (a measure of statistical significance) in placebo groups had nearly doubled over that time.
It's not that the old meds are getting weaker, drug developers say. It's as if the placebo effect is somehow getting stronger.
Intruiged? Go, read.
EWW!
Well, unsurprisingly, anti-gay [marriage] groups in Maine are rolling around in the mud. I just read the transcript of the ads they're trying to air, and I feel dirty. From Right Wing Watch, comes the transcript of an ad called "The New Curriculum":
School Administrator (talking to an off-camera mic/reporter–as he talks, we see images of teachers in classrooms reading from blurred-out books, GLSEN-style posters, etc.): No, we’re very proud of the new curriculum. It’s all about teaching kids to embrace different lifestyles and explore their own sexuality.
Switching from images of sex ed classrooms to little boy on a bench in a darkened school hallway. We can see an adult male (not his face, we’re looking from the perspective of the child and the view never includes his head) come out of an office, take the boy’s hand, lead him into the office, and close the door. Freeze on the closed door, which has a sign that says, “Counseling Session: Do Not Disturb”
Reporter (VO) : Yes, but is it appropriate for kindergartners to be receiving counseling about whether they might be gay?
School Admin (VO): Sure, we’ve had a few complaints, but there’s not much parents can do. It’s the law, after all.
VO: Think gay marriage won’t affect your family? Think again.
Vote Yes Graphic
I honestly thought it was a spoof.
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